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Gastric myeloid sarcoma: A case report.

Patricia Rioja1, Jackeline Macetas1, Jorge Luna-Abanto2

  • 1Department of Oncology Medicine, Instituto Nacional de Enfermedades Neoplásicas, Lima 15000, Peru.

World Journal of Clinical Oncology
|November 4, 2021
PubMed
Summary

Primary gastric myeloid sarcoma (MS) is a rare and aggressive cancer. This case highlights the challenges in managing this rare extramedullary tumor, emphasizing the need for further research.

Keywords:
Case reportChemotherapyGranulocytic sarcomaMyeloid sarcomaPeruStomach

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Myeloid sarcoma (MS) is a rare extramedullary tumor of immature granulocytic cells.
  • It can be primary or associated with myelodysplastic/myeloproliferative neoplasms.
  • Commonly affects skin, lymph nodes, and bones.

Observation:

  • A 19-year-old female presented with a large primary de novo gastric MS.
  • Imaging revealed a 16.5 cm gastric tumor with regional infiltration.
  • Histology confirmed diffuse infiltration by myeloperoxidase-positive cells.

Findings:

  • The patient received induction chemotherapy (3+7 regimen) with severe toxicity.
  • She developed neutropenic typhlitis and disease progression.
  • Despite supportive care, the patient succumbed to the disease.

Implications:

  • Primary gastric MS is rare, aggressive, and challenging to manage.
  • Increased understanding of this pathology is crucial for treatment strategies.
  • Further research is needed to explore unique aspects of gastric MS.