Oral amyloidosis: two unusual case presentations

Two cases of oral amyloidosis are reported. In each case there were unusual oral manifestations. In the first case the patient's only complaints were of recurrent swelling of the submandibular glands and xerostomia. The diagnosis of amyloidosis was determined from a labial salivary gland biopsy. In the second case an enlarged tongue had produced displacement of the teeth, causing malocclusion. The resulting difficulty in chewing stimulated the patient to seek advice. In each case the diagnosis was confirmed by electron microscopy, Congo red staining, and serum and urine electrophoresis.