Imaging the temporal dynamics of brain states with highly sampled fMRI

The spontaneous dynamics of the brain modulate its function from moment to moment, shaping neural computation and cognition. Functional MRI (fMRI), while classically used as a tool for spatial localization, is increasingly being used to identify the temporal dynamics of brain activity. fMRI analyses focused on the temporal domain have revealed important new information about the dynamics underlying states such as arousal, attention, and sleep. Dense temporal sampling - either by using fast fMRI acquisition, or multiple repeated scan sessions within individuals - can further enrich the information present in these studies. This review focuses on recent developments in using fMRI to identify dynamics across brain states, particularly vigilance and sleep states, and the potential for highly temporally sampled fMRI to answer these questions.