Related Experiment Video
Updated: Oct 14, 2025
Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Influenza Virus Associated Pediatric Acute Respiratory Distress Syndrome: Clinical Characteristics and Outcomes
Nazik Yener1, Muhammed Üdürgücü1, Resul Yılmaz2
1Division of Pediatric Critical Care, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.
Insights
Influenza A and B cause severe pediatric acute respiratory distress syndrome (PARDS) with high mortality (33%) and morbidity (15.5%). Young children and those previously healthy are at significant risk.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Respiratory medicine
Background:
- Pediatric acute respiratory distress syndrome (PARDS) is a severe condition.
- Influenza virus is a known cause of respiratory illness in children.
- The 2019-20 season saw significant influenza activity.
Purpose of the Study:
- To investigate the clinical features of PARDS caused by influenza.
- To analyze treatment strategies for influenza-related PARDS.
- To determine the outcomes of children with influenza-related PARDS.
Main Methods:
- Multicenter retrospective study.
- Inclusion criteria: 1 month to 18 years diagnosed with PARDS associated with influenza during the 2019-20 season.
- Data collected on clinical characteristics, treatment, and outcomes.
Main Results:
- Sixty-seven patients were included; 60% were under 5 years old.
- Influenza A (80.5%) and B (19.5%) were identified. Most patients (73.1%) had comorbidities.
- 33% mortality and 15.5% morbidity were observed. Severe PARDS occurred in 52.5% of patients, with 86.6% requiring invasive mechanical ventilation.
Conclusions:
- Both Influenza A and B cause severe PARDS with similar, high rates.
- Influenza-related PARDS has a significant mortality (33%) and morbidity (15.5%) rate.
- Previously healthy children, particularly those under 5, are vulnerable to severe outcomes.
Background And Objective:
The aim of this multicenter retrospective study was to determine the clinical characteristics, treatment approaches and the course of pediatric acute respiratory distress syndrome (PARDS) which developed associated with the influenza virus in the 2019-20 season.
Methods:
Patients included 1 month to 18 years who were diagnosed with PARDS associated with the influenza virus in the 2019-20 season.
Results:
Sixty-seven patients were included in the study. The mean age of the patients was 64.16 ± 6.53 months, with 60% of the group <5 years. Influenza A was determined in 54 (80.5%) patients and Influenza B in 13 (19.5%). The majority of patients (73.1%) had a comorbidity. Fifty-eight (86.6%) patients were applied with invasive mechanical ventilation, Pediatric Acute Lung Injury Consensus Conference classification was mild in 5 (8.6%), moderate in 22 (37.9%) and severe in 31 (52.5%) patients. Ventilation was applied in the prone position to 40.3% of the patients, and in nonconventional modes to 24.1%. A total of 22 (33%) patients died, of which 4 had been previously healthy. Of the surviving 45 patients, 38 were discharged without support and 7 patients with a new morbidity.
Conclusion:
Both Influenza A and Influenza B cause severe PARDS with similar characteristics and at high rates. Influenza-related PARDS cause 33% mortality and 15.5% morbidity among the study group. Healthy children, especially those aged younger than 5 years, are also at risk.
More Related Videos
06:22Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
09:36Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Related Concept Videos
01:23Acute Respiratory Failure-IV
01:29Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:21Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
01:21Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:30Acute Respiratory Failure-III
01:30Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause: