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Reporter Genes

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.

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Updated: Oct 14, 2025

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Ultrasmall compact CMOS imaging system for bioluminescence reporter-based live gene expression analysis.

Joshua Philippe Olorocisimo^1,2, Jeric Briones^3,4, Kiyotaka Sasagawa¹

¹Nara Institute of Science and Technology, Photonics Device Science Laboratory, Division of Materials, Japan.

Journal of Biomedical Optics

|November 4, 2021

Summary

Researchers developed a compact bioluminescence imaging system using micro-CMOS image sensors (μCIS) for live gene expression analysis. This cost-effective device offers higher sensitivity and clearer signals for biomedical research.

Keywords:

bioluminescence biophotonics gene expression image sensors luciferase micro-CMOS

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Last Updated: Oct 14, 2025

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Area of Science:

Biomedical Research
Molecular Biology
Imaging Technology

Background:

Live gene expression imaging is crucial but limited by conventional optical devices and fluorescent reporters.
Bioluminescence imaging offers advantages over fluorescence for gene expression analysis.

Purpose of the Study:

To develop a smaller, cost-effective, and versatile imaging system for bioluminescence reporter-based gene expression analysis.
To overcome limitations of existing technologies for live gene expression imaging.

Main Methods:

Development of a compact imaging system utilizing micro-CMOS image sensors (μCIS).
Implementation of an improved pixel design and a patterned absorption filter array for enhanced low-light detection.
Characterization of the system's performance, including dark current, temporal noise, and sensitivity.

Main Results:

The μCIS system demonstrated significantly lower dark current and temporal noise.
Higher sensitivity was achieved compared to previous designs, enabling clearer light signal detection.
Successful measurement of bioluminescence reporter-based gene expression in living mammalian cells.

Conclusions:

The developed μCIS system provides a cost-effective and versatile solution for bioluminescence imaging.
Future applications include in vivo implantation for simultaneous gene expression imaging, behavioral analysis, and optogenetic modulation.