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Updated: Oct 14, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis
Chao Ding1, Yaoyu Ren1, Caocao Sun1
1The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, P. R. China.
Abstract:
Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis.
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