Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.2K
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

12
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
12
Drug Therapy01:28

Drug Therapy

118
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
118
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

29
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
29
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

26
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
26
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

19
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Data Integrity in Medical AI.

Studies in health technology and informatics·2026
Same author

Differentiating long QT syndrome genotypes using electrocardiographic geometric parameterization and machine learning approaches.

Biomedical physics & engineering express·2026
Same author

Bioengineering Innovations for Personalized Care in Low Back Pain: From Sensors to Smart Therapeutics.

Bioengineering (Basel, Switzerland)·2026
Same author

How does it affect the willingness to continue rehabilitation training? A usability evaluation of a multi-sensory rehabilitation interactive game system (MRIGS) for older adults with mild dementia.

Computers in biology and medicine·2025
Same author

Cardiac Rhythm Conversions and the Outcome in Refractory Out-of-Hospital Cardiac Arrest: Extracorporeal Versus Conventional Resuscitation.

Critical care medicine·2025
Same author

Lower cholesterol level on admission predicts poor outcome after prolonged cardiac arrest.

Scientific reports·2025

Related Experiment Video

Updated: Oct 14, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.8K

Towards Personalized Medication.

Michal Huptych1, Jiri Potucek1,2, Lenka Lhotská1,3

  • 1Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Prague, Czech Republic.

Studies in Health Technology and Informatics
|November 4, 2021
PubMed
Summary

Precision medicine relies on pharmacokinetics and pharmacodynamics (PKPD) for effective drug monitoring and dosing. This study introduces an intelligent search engine prototype to improve literature searches for PKPD model development.

Keywords:
Precision medicineintelligent literature searchmodel-informed precision dosingpharmacodynamicspharmacokinetics

More Related Videos

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K
Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
08:26

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Published on: February 23, 2024

2.2K

Related Experiment Videos

Last Updated: Oct 14, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.8K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.4K
Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
08:26

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Published on: February 23, 2024

2.2K

Area of Science:

  • Pharmacology
  • Computational Biology
  • Drug Development

Background:

  • Precision medicine necessitates accurate pharmacokinetic and pharmacodynamic (PKPD) models.
  • Therapeutic drug monitoring and model-informed precision dosing are crucial for optimizing patient outcomes.
  • Current literature search tools lack specialized functionalities for efficient and relevant drug discovery research.

Purpose of the Study:

  • To highlight the importance of PKPD in precision medicine.
  • To address the limitations of existing search engines for scientific literature relevant to drug development.
  • To introduce a prototype intelligent search engine designed for PKPD model development.

Main Methods:

  • Described aspects of precision medicine and the role of PKPD.
  • Identified limitations in current literature search engines for drug discovery.
  • Developed and tested a prototype intelligent search engine.

Main Results:

  • The prototype intelligent search engine demonstrated effective retrieval of relevant literature for PKPD model design.
  • The tool addresses the need for specialized search functionalities in drug development.
  • Real project data validated the engine's performance.

Conclusions:

  • An intelligent search engine can significantly enhance the efficiency and relevance of literature searches for PKPD model development.
  • Improved literature search capabilities are vital for accelerating drug procurement and validation.
  • The developed prototype shows promise for advancing precision medicine research.