Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiated Thyroid Cancer Is Associated With Sex-specific Immune Response.

Journal of the Endocrine Society·2025
Same author

A de novo dominant-negative PSMB8 mutation causes severe CANDLE/PRAAS due to arrested proteasome biogenesis.

Annals of the rheumatic diseases·2025
Same author

Oropouche virus efficiently replicates and is immunostimulatory in vivo in nonhuman primate species.

Science advances·2025
Same author

Repeated enema administration in rhesus macaques is not sufficient to promote bacterial dysbiosis or gastrointestinal dysfunction.

Mucosal immunology·2025
Same author

Mpox multiprotein virus-like nanoparticle vaccine induces neutralizing and protective antibodies in mice and non-human primates.

Nature communications·2025
Same author

Interaction of the endogenous antibody response with activating FcγRs enhance control of Mayaro virus through monocytes.

PLoS pathogens·2025

Related Experiment Video

Updated: Oct 14, 2025

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.3K

Microbiome Studies in Non-human Primates.

Jason M Brenchley1, Alexandra M Ortiz1

  • 1Barrier Immunity Section, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, USA.

Current HIV/AIDS Reports
|November 4, 2021
PubMed
Summary
This summary is machine-generated.

The gut microbiome

Keywords:
DysbiosisHIVMicrobiomeNon-human primateSIV

More Related Videos

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.4K
Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
03:39

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates

Published on: November 8, 2024

647

Related Experiment Videos

Last Updated: Oct 14, 2025

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.3K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.4K
Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
03:39

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates

Published on: November 8, 2024

647

Area of Science:

  • Microbiome research
  • HIV/SIV pathogenesis
  • Animal models in infectious disease

Background:

  • Human studies show altered gut microbiomes in people living with HIV.
  • Non-human primate (NHP) models offer controlled environments to study microbiome contributions to HIV/SIV.
  • Standardizing environmental factors in NHP models aids microbiome research.

Purpose of the Study:

  • To review findings on microbiome contributions to HIV disease using NHP models.
  • To highlight the role of the gut microbiome in HIV pathogenesis.
  • To assess the utility of NHP models in microbiome-HIV research.

Main Methods:

  • Review of existing literature on microbiome and SIV infection in NHPs.
  • Analysis of studies standardizing environmental confounders in NHP models.
  • Examination of multi-omics and interventional study designs.

Main Results:

  • Inconsistent observations of bacterial intestinal microbiome differences in SIV-infected NHPs.
  • Attributed differences in lentiviral susceptibility and vaccine efficacy to microbiome variations, but not experimentally confirmed.
  • Compelling associations exist, but clear contributions of the microbiome to HIV/SIV disease remain undefined.

Conclusions:

  • Further research using comprehensive multi-omics and longitudinal/interventional studies in NHP models is crucial.
  • Defining the microbiome's role in HIV and SIV pathogenesis requires rigorous experimental approaches.
  • NHP models are essential for dissecting the complex interplay between the microbiome and lentiviral infections.