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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
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Updated: Oct 14, 2025

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Celiac Disease in Children.

Jennifer Jimenez1, Beth Loveridge-Lenza1, Karoly Horvath2

  • 1Division of Pediatric Gastroenterology and Nutrition, Jersey Shore University Medical Center, K. Hovnanian Children's Hospital, Hackensack Meridian Health, 19 Davis Avenue, 5th Floor, Neptune, NJ 07753, USA.

Pediatric Clinics of North America
|November 5, 2021
PubMed
Summary

Celiac disease is an autoimmune disorder triggered by gluten. Diagnosis involves antibody tests and intestinal biopsies, with lifelong gluten-free diets being the primary management strategy.

Keywords:
Celiac diseaseGluten-free dietOther gluten-related conditionsSymptoms of celiac diseaseTissue transglutaminase-2 test

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Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Celiac disease is an autoimmune enteropathy.
  • It is triggered by gluten ingestion in genetically susceptible individuals.

Purpose of the Study:

  • To outline the diagnostic and management strategies for celiac disease.

Main Methods:

  • Screening involves measuring serum IgA antibodies to tissue transglutaminase-2.
  • Diagnosis is confirmed by small intestinal biopsies showing mucosal damage in patients with specific antibodies.

Main Results:

  • Serum IgA antibodies to tissue transglutaminase-2 offer high sensitivity and specificity for screening.
  • Confirmation relies on identifying both circulating antibodies and intestinal mucosal damage.

Conclusions:

  • Early screening and accurate diagnosis are crucial for celiac disease management.
  • Lifelong adherence to a gluten-free diet and continuous follow-up are essential for patient health.