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Updated: Oct 14, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

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Published on: April 21, 2023

Microbiota and nanoparticles: Description and interactions.

Abdallah Ladaycia¹, Catherine Passirani¹, Elise Lepeltier¹

¹Micro et Nanomédecines Translationnelles, MINT, UNIV Angers, UMR INSERM 1066, UMR CNRS 6021, Angers, France.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|November 5, 2021

Summary

The human body hosts bacteria crucial for health. Nanoparticles can impact this microbiota, potentially causing disease or offering therapeutic solutions.

Keywords:

Antibacterial Dysbiosis Restoring Targeting Toxicity

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Area of Science:

Microbiology
Nanotechnology
Toxicology

Background:

The human body hosts a vast bacterial microbiota essential for health.
Alterations in microbiota composition are linked to various diseases.
Nanoparticles are increasingly used in diverse applications, including medicine.

Purpose of the Study:

To explore the interactions between nanoparticles and the human microbiota.
To understand how nanoparticles affect microbiota stability and health.
To investigate the potential of nanoparticles in microbiota regulation and disease treatment.

Main Methods:

Review of existing literature on nanoparticle-microbiota interactions.
Analysis of studies detailing nanoparticle effects on microbial communities.
Examination of nanoparticle-based therapeutic strategies for microbiota disorders.

Main Results:

Nanoparticle interactions with microbiota vary based on nanoparticle properties (nature, structure, concentration).
Effects range from destabilization and toxicity to restoration of microbial balance.
Nanoparticles show potential as therapeutic agents for microbiota-related conditions.

Conclusions:

Nanoparticles can significantly influence the human microbiota.
Understanding these interactions is key to harnessing nanoparticles for health benefits.
Further research is needed to optimize nanoparticle applications for microbiota management.