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Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
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Functional connectivity of anterior retrosplenial cortex in object recognition memory
Ana Belén de Landeta1, Magdalena Pereyra1, Magdalena Miranda2
1Universidad de Buenos Aires, Facultad de Medicina, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Biología Celular y Neurociencia "Prof. E. De Robertis" (IBCN), Buenos Aires, Argentina.
Neurobiology of Learning and Memory
|November 5, 2021
Summary
The anterior retrosplenial cortex (aRSC) interacts with several brain regions to consolidate object recognition memory. Inactivation studies reveal specific pathways crucial for memory formation.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Memory Research
Background:
- Object recognition (OR) memory involves
- "what", "where", and "when" components.
Purpose of the Study:
- Investigate brain structures interacting with the anterior retrosplenial cortex (aRSC) for OR memory consolidation in rats.
- Identify specific cortico-cortical and cortico-thalamic pathways involved in OR memory processing.
Main Methods:
- Bilateral microinfusions of muscimol to inactivate specific brain regions (mPFC, AM, MEC, ACC).
- Unilateral inactivation of aRSC and connected structures (ipsilateral and contralateral hemispheres).
Main Results:
- Inactivation of mPFC, AM, and MEC impaired OR long-term memory (LTM).
- Ipsilateral aRSC-PRH, aRSC-mPFC, aRSC-AM, and aRSC-MEC inactivations caused amnesia.
- Contralateral aRSC-ACC inactivation impaired memory; aRSC-dHP inactivation had no effect.
Conclusions:
- The aRSC, along with regions like PRH, mPFC, AM, and MEC, is essential for OR LTM consolidation.
- Specific cortico-cortical and cortico-thalamic pathways play critical roles in OR memory consolidation.
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