Frequency and associations of HLA-DR and HLA-DQ antigens in a British Caucasoid panel

The frequencies of the HLA-DR and -DQ antigens, including those of the new specificities "DRBr" and TA10, were established in a random panel of 286 British Caucasoids. The most frequent DR antigens were DR2, DR4 and DR7. The DR-DQ antigen associations were examined and the only heterogeneity found was with DR7 which was found to be associated predominantly with DQw2 but also with DQw3. The DR4's were subdivided into those positive and those negative for TA10 and DR4-TA10 was found to be associated with HLA-B44.