Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.4K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.7K
Synthetic Biology02:55

Synthetic Biology

5.0K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.0K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

3.6K
3.6K
Pedigree Analysis01:35

Pedigree Analysis

86.0K
Overview
86.0K
Homologous Recombination02:31

Homologous Recombination

5.1K
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proposed Framework for Adopting Privacy-Preserving Record Linkage for Public Health Action.

Journal of public health management and practice : JPHMP·2024
Same author

Privacy preserving record linkage for public health action: opportunities and challenges.

Journal of the American Medical Informatics Association : JAMIA·2024
Same author

Evaluating data quality for blended data using a data quality framework.

Statistical journal of the IAOS·2024
Same author

A Comparison of the Mortality Experience of U.S. Adults Estimated With the 2006-2018 National Health Interview Survey Linked Mortality Files and the Annual U.S. Life Tables.

National health statistics reports·2023
Same author

A methodological assessment of privacy preserving record linkage using survey and administrative data.

Statistical journal of the IAOS·2022
Same author

Using supervised machine learning to identify efficient blocking schemes for record linkage.

Statistical journal of the IAOS·2021
Same journal

Estimating an intervention's effects on health care disparities within and between physician organizations: decomposing the effects of health system affiliation.

Health services & outcomes research methodology·2026
Same journal

Gaming the System: Evaluating Spillover in a Video Game Intervention for Advance Care Planning using Physician Social Networks.

Health services & outcomes research methodology·2026
Same journal

A causal framework for evaluating drivers of policy effect heterogeneity using difference-in-differences.

Health services & outcomes research methodology·2026
Same journal

Choosing an analytic approach: key study design considerations in state policy evaluation.

Health services & outcomes research methodology·2026
Same journal

The challenges of integrating diverse data sources: A case study in major depression.

Health services & outcomes research methodology·2026
Same journal

The impact of knowledge of hospitalization on mortality predictions.

Health services & outcomes research methodology·2026
See all related articles

Related Experiment Video

Updated: Oct 14, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.3K

Using Synthetic Data to Replace Linkage Derived Elements: A Case Study.

Dean M Resnick1, Christine S Cox1, Lisa B Mirel2

  • 1NORC at the University of Chicago, Bethesda, Maryland.

Health Services & Outcomes Research Methodology
|November 5, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces synthetic data to protect patient privacy when linking hospital records with mortality data. Replacing sensitive information with synthetic values allows for robust survival analyses while mitigating re-identification risks.

Keywords:
National Center for Health StatisticsNational Death IndexNational Hospital Care Survey Linked Mortality DataSurvival AnalysisSynthetic Data

More Related Videos

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.4K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.4K

Related Experiment Videos

Last Updated: Oct 14, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.3K
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.4K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.4K

Area of Science:

  • Health Informatics
  • Biostatistics
  • Data Privacy

Background:

  • Record linkage enhances survey data but increases privacy risks.
  • The National Hospital Care Survey (NHCS) linked with the National Death Index (NDI) offers survival analysis capabilities.
  • Detailed mortality data (dates, causes of death) linked to patient records heighten re-identification risks for deceased individuals.

Purpose of the Study:

  • To develop and evaluate a synthetic data approach for protecting patient privacy in linked NHCS-NDI data.
  • To assess the utility of synthetic mortality data for survival analyses.
  • To mitigate privacy risks associated with linking patient records with mortality information.

Main Methods:

  • Utilized survival analysis models to generate synthetic vital status and dates of death.
  • Employed classification tree analysis to synthesize causes of death.
  • Compared survival analysis parameter estimates from actual and synthetic data.

Main Results:

  • The study evaluated the degree to which analyses on synthetic data replicate results from actual data.
  • Comparison focused on survival analysis parameter estimates.
  • This evaluation is crucial for assessing the utility of synthetic mortality data.

Conclusions:

  • The developed synthetic data approach shows potential for privacy preservation in linked health and mortality datasets.
  • Synthetic mortality data can potentially support robust survival analyses while safeguarding patient confidentiality.
  • Further assessment is needed to confirm the utility of synthetic data for statistical estimation.