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Updated: Oct 14, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Coexpression network analysis identified lncRNAs-mRNAs with potential relevance in African ancestry prostate cancer
Rafael Parra-Medina1,2,3, Liliana López-Kleine4, Sandra Ramírez-Clavijo1
1Faculty of Natural Sciences, Universidad del Rosario, Bogotá, Colombia.
Aim:
This study aims to investigate similarities and differences using lncRNA and mRNA coexpression network analysis in African ancestry (AA) and European ancestry (EA) among prostate cancer (PCa) patients.
Methods:
We performed weighted gene coexpression network analysis of the expression from 49 of AA and 49 of EA to identify lncRNAs-mRNAs.
Results:
27 lncRNAs and 36 mRNAs were highly expressed in patients of AA. Two mRNAs and their antisense lncRNAs were expressed. Additionally, seven mRNAs were DE or coexpressed and had an impact on survival.
Conclusion:
We present a list of lncRNAs and mRNAs that were DE and coexpressed when comparing patients of AA and EA, and these data are a resource for future studies to understand the role of lncRNAs.
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