Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Warburg effect provides attributes that facilitate tumor-cell resistance.

Histology and histopathology·2026
Same author

Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells.

ACS chemical biology·2026
Same author

Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression.

Cell reports·2025
Same author

Transcriptomic and Proteomic Profiles for Elucidating Cisplatin Resistance in Head-and-Neck Squamous Cell Carcinoma.

Cancers·2022
Same author

Editorial: Sphingolipid metabolism and cancer.

Frontiers in oncology·2022
Same author

Understanding RNA-binding proteins.

Seminars in cancer biology·2022

Related Experiment Video

Updated: Oct 14, 2025

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.6K

Targeting Sphingolipids for Cancer Therapy.

Osmel Companioni1, Cristina Mir1, Yoelsis Garcia-Mayea1

  • 1Biomedical Research in Cancer Stem Cells Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Frontiers in Oncology
|November 5, 2021
PubMed
Summary

Sphingolipid-targeting drugs show promise in cancer treatment, with fenretinide and α-galactosylceramide being most effective. Clinical trial outcomes vary, highlighting the need for further research into these cancer therapies.

Keywords:
cancerclinical studiespreclinicalsphingolipidstherapy

More Related Videos

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.6K
Preparation of Human Tissues Embedded in Optimal Cutting Temperature Compound for Mass Spectrometry Analysis
09:09

Preparation of Human Tissues Embedded in Optimal Cutting Temperature Compound for Mass Spectrometry Analysis

Published on: April 27, 2021

2.3K

Related Experiment Videos

Last Updated: Oct 14, 2025

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.6K
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
12:27

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

3.6K
Preparation of Human Tissues Embedded in Optimal Cutting Temperature Compound for Mass Spectrometry Analysis
09:09

Preparation of Human Tissues Embedded in Optimal Cutting Temperature Compound for Mass Spectrometry Analysis

Published on: April 27, 2021

2.3K

Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • Sphingolipids play crucial roles in cellular functions, including proliferation and cell death.
  • Aberrant sphingolipid metabolism is implicated in cancer progression, proliferation, and metastasis.
  • Several sphingolipid signaling modulators have been developed for potential cancer therapies.

Purpose of the Study:

  • To review and analyze preclinical and clinical trial data of sphingolipid-targeting drugs for cancer treatment.
  • To evaluate the efficacy and safety of these agents, alone or in combination with chemotherapy.
  • To discuss the mechanisms of action and therapeutic potential of sphingolipid modulation in oncology.

Main Methods:

  • Literature review of preclinical studies (in vitro and in vivo) and clinical trials.
  • Analysis of drug efficacy, mechanisms of cell death (apoptosis, autophagy), and adverse effects.
  • Comparison of outcomes for various sphingolipid-targeting agents including fenretinide, safingol, ABC294640, ceramide nanoliposomes (CNLs), SKI-II, α-galactosylceramide (α-GalCer), fingolimod, and sonepcizumab.

Main Results:

  • Sphingolipid-targeting drugs demonstrated antitumor activity and synergism with chemotherapy in preclinical settings.
  • Fenretinide and α-galactosylceramide showed the most significant efficacy.
  • Clinical trial results were inconsistent; ABC294640 and safingol exhibited specific toxicities, while others lacked sufficient clinical data.

Conclusions:

  • Sphingolipid modulation presents a viable strategy for cancer therapy, though clinical success varies among agents.
  • Fenretinide and α-galactosylceramide are promising candidates for further clinical development.
  • Further research is needed to overcome limitations and fully elucidate the therapeutic benefits of sphingolipid-targeting drugs in cancer treatment.