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Updated: Oct 14, 2025

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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Big mitral annular calcification: a case report of a dynamic liquefaction necrosis as a potential source of embolism

Simon M Frey1, Verena Hofmann2, Michael J Zellweger1

  • 1Department of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

European Heart Journal. Case Reports
|November 5, 2021
PubMed
Abstract

Insights

Caseous mitral annular calcification (cMAC) is a rare condition. Cardiac magnetic resonance (CMR) can diagnose cMAC and monitor its dynamic changes, which may lead to serious complications like stroke.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Mitral annular calcification (MAC) is a common degenerative condition, typically asymptomatic in the elderly.
  • Caseous MAC (cMAC) is a rare variant with central liquefaction necrosis, primarily affecting the posterior mitral annulus.
  • Optimal management strategies for cMAC remain undefined, despite potential for severe complications.
Keywords:
Cardiac magnetic resonanceCardiac massCase reportCaseous mitral annular calcificationDynamic liquefaction of mitral annular calcificationMulti-parametric tissue characterization

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