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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP

Melissa J Ruggiero1, Haley Miller1, Jessica Y Idowu1

  • 1Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

Livers
|November 5, 2021
PubMed
Summary

Perfluoroalkyl carboxylates, including PFOA, PFNA, and PFDA, are substrates of the Na+/taurocholate cotransporting polypeptide (NTCP). These compounds interact with NTCP, potentially affecting bile acid transport and perfluoroalkyl substance elimination.

Keywords:
perfluoroalkyl acidsperfluoroalkyl carboxylatestaurocholate transport

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