[Platelet function tests and Chinese medicines with antiplatelet function:a review].

Area of Science:

• Pharmacology
• Traditional Chinese Medicine
• Biochemistry

Background:

• Platelet function tests are crucial for diagnosing platelet disorders, assessing thrombotic risk, and monitoring antiplatelet therapy.
• While light transmission aggregometry is established, novel platelet function tests are emerging.
• Platelet function detector development in China is still in its early stages.

Purpose of the Study:

• To review and analyze methods for determining platelet function.
• To summarize research on the antiplatelet effects of Chinese medicines and their active constituents.
• To provide insights for developing effective and safe antiplatelet Chinese medicines.

Main Methods:

• Classification of active constituents in antiplatelet Chinese medicines (terpenoids, flavonoids, etc.).
• Analysis of dose-response relationships for Chinese medicines and their active components.
• Identification of specific compounds like salvianolic acid B and ginkgolides with potent antiplatelet activity.

Main Results:

• Effective concentrations of Chinese medicine extracts/monomers are in the micromolar range (μmol·L⁻¹).
• Salvianolic acid B, ginkgolide K, B, and A exhibit the strongest antiplatelet effects.
• The antiplatelet effects of Chinese medicines involve multiple pathways and targets, potentially weaker than chemical drugs.

Conclusions:

• Chinese medicines offer potential for antiplatelet therapy, but efficacy may require structure-activity relationship exploration and modification.
• Large-scale clinical trials are needed to validate the efficacy and safety of these agents.
• Further research into signal transduction pathways and structure-activity relationships is essential.