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Updated: Oct 14, 2025

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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[Platelet function tests and Chinese medicines with antiplatelet function:a review].

Shun-Li Xiao1, Shi-Lan Ding1, Zheng-Xiao Sun1

  • 1Institute of Chinese Materia Media, China Academy of Chinese Medical Sciences Beijing 100700, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|November 5, 2021
PubMed
Summary

Chinese medicines contain active constituents with antiplatelet effects, primarily at micromolar levels. Further research into structure-activity relationships is needed to enhance their efficacy compared to conventional drugs.

Keywords:
Chinese medicineantiplateletmechanismsplatelet function tests

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Area of Science:

  • Pharmacology
  • Traditional Chinese Medicine
  • Biochemistry

Background:

  • Platelet function tests are crucial for diagnosing platelet disorders, assessing thrombotic risk, and monitoring antiplatelet therapy.
  • While light transmission aggregometry is established, novel platelet function tests are emerging.
  • Platelet function detector development in China is still in its early stages.

Purpose of the Study:

  • To review and analyze methods for determining platelet function.
  • To summarize research on the antiplatelet effects of Chinese medicines and their active constituents.
  • To provide insights for developing effective and safe antiplatelet Chinese medicines.

Main Methods:

  • Classification of active constituents in antiplatelet Chinese medicines (terpenoids, flavonoids, etc.).
  • Analysis of dose-response relationships for Chinese medicines and their active components.
  • Identification of specific compounds like salvianolic acid B and ginkgolides with potent antiplatelet activity.

Main Results:

  • Effective concentrations of Chinese medicine extracts/monomers are in the micromolar range (μmol·L⁻¹).
  • Salvianolic acid B, ginkgolide K, B, and A exhibit the strongest antiplatelet effects.
  • The antiplatelet effects of Chinese medicines involve multiple pathways and targets, potentially weaker than chemical drugs.

Conclusions:

  • Chinese medicines offer potential for antiplatelet therapy, but efficacy may require structure-activity relationship exploration and modification.
  • Large-scale clinical trials are needed to validate the efficacy and safety of these agents.
  • Further research into signal transduction pathways and structure-activity relationships is essential.