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Microfluidic chip connected to porous microneedle array for continuous ISF sampling.

Kai Takeuchi1,2, Nobuyuki Takama3, Kirti Sharma4,5

  • 1Institute of Industrial Science, the University of Tokyo, Tokyo, Japan. takekai@iis.u-tokyo.ac.jp.

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Summary
This summary is machine-generated.

This study presents a new microneedle (MN) biosensing system for continuous healthcare monitoring. The device integrates porous microneedles with a microfluidic chip for minimally invasive interstitial fluid sampling.

Keywords:
BiosensingGlucose monitoringMicrochannelMicroneedle

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Area of Science:

  • Biomedical Engineering
  • Microneedle Technology
  • Biosensing

Background:

  • Minimally invasive biosensing using microneedles (MNs) is crucial for continuous healthcare monitoring.
  • Porous MNs offer potential for interstitial fluid (ISF) sampling, bridging tissue to external devices.
  • Integrating porous MNs with microfluidic chips is key for micro-total analysis systems (μTAS).

Purpose of the Study:

  • To develop a fluidic system for direct interfacing of porous MNs to a microfluidic chip.
  • To enable continuous sampling of ISF via porous MNs for biomarker analysis.
  • To advance minimally invasive biosensing for long-term healthcare applications.

Main Methods:

  • Fabrication of porous and flexible MNs from PDMS.
  • Integration of MNs with a microfluidic chip using standard micro-electro-mechanical system (MEMS) processes.
  • Incorporation of a capillary pump for continuous ISF sampling.

Main Results:

  • Demonstrated successful connection of PDMS porous MNs to the microfluidic chip.
  • Confirmed continuous flow of phosphate buffered saline (PBS) through the integrated system.
  • Validated the potential for continuous ISF sampling.

Conclusions:

  • The developed fluidic system enables direct interfacing of porous MNs with microfluidic chips.
  • This technology facilitates minimally invasive, continuous biosampling for long-term healthcare monitoring.
  • The system is a promising step towards advanced micro-total analysis systems (μTAS).