Capturing of Magnetic Nanoparticles in a Fluidic Channel for Magnetic Drug Targeting

In this work, the capturing of magnetic nanoparticles has been explored through a mathematical model and in-vitro study in a cylindrical tube under the influence of an applied magnetic field. In the formulation of the model, the dominant magnetization and drag forces are included that extensively affect the capturing of magnetic nanoparticles. Model results indicates that the value of capture efficiency (CE) improves 23 to 51% for the magnetic field 0.1 to 0.5 T, respectively. It is further noticed through in-vitro experimental results that capturing of magnetic particles increases by the external magnetic field, applied through an electromagnet at the centre of the cylindrical tube. The experimental value of capture efficiency is calculated via the analysis of the captured images of the particles and Atomic Absorption Spectroscopy (AAS) data. The in-vitro experimental and model results are compared, which demonstrates good agreement and consequently validates the mathematical model.