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A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
Altab Shaikh1,2, Praveen Kumar Neeli2,3, Gajalakshmi Singuru2,3
1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad-500007, India.
Chemical Communications (Cambridge, England)
|November 5, 2021
Abstract:
Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.
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