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Time to fixation in changing environments.

Sachin Kaushik1, Kavita Jain1

  • 1Theoretical Sciences Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.

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|November 5, 2021
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Summary
This summary is machine-generated.

Environmental changes impact natural selection. We studied fixation times for beneficial and deleterious mutations in changing environments, finding recessive deleterious mutations are strongly affected, unlike beneficial ones.

Keywords:
changing environmentdominancefixation timeselective sweeps

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Area of Science:

  • Evolutionary biology
  • Population genetics
  • Theoretical ecology

Background:

  • Natural selection studies often assume constant environments, but natural settings fluctuate.
  • Understanding evolution in changing environments is crucial for ecological and genetic insights.

Purpose of the Study:

  • To investigate how a periodically changing environment affects the conditional fixation time of new mutations.
  • To compare fixation times of beneficial and deleterious mutants in dynamic versus static environments.

Main Methods:

  • Mathematical modeling of a finite, randomly mating diploid population.
  • Analysis of conditional fixation time for mutants with intermediate dominance.
  • Comparison of results under slowly varying and static environmental conditions.

Main Results:

  • The symmetry in fixation times between beneficial and deleterious mutants (seen in static environments) is broken in changing environments.
  • Initially beneficial mutants show fixation times weakly dependent on dominance and close to static environment results.
  • Recessive deleterious mutants exhibit significantly altered fixation times in changing environments compared to constant ones.

Conclusions:

  • Temporal environmental variation has a mild effect on genetic diversity patterns for beneficial sweeps.
  • Environmental fluctuations can strongly influence genetic diversity patterns arising from recessive deleterious sweeps.