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Tissue levels of ofloxacin in the urogenital system

F di Silverio, E Cruciani, G Ferrone

    Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
    |April 1, 1987
    PubMed

    Insights

    This study measured ofloxacin tissue levels in patients undergoing surgery for urogenital conditions. Ofloxacin demonstrated prompt and high distribution in urinary tract tissues, suggesting effective therapeutic concentrations.

    Area of Science:

    • Pharmacology
    • Urology
    • Clinical Pharmacy

    Background:

    • Ofloxacin is a fluoroquinolone antibiotic commonly used for bacterial infections.
    • Understanding its tissue distribution is crucial for optimizing treatment efficacy in urogenital diseases.
    • Pre-operative drug levels can inform surgical site infection prophylaxis.

    Purpose of the Study:

    • To determine the tissue concentrations of ofloxacin in various parts of the urogenital system.
    • To compare achieved tissue levels with minimum inhibitory concentrations (MIC80) of relevant bacterial strains.
    • To assess the pharmacokinetic profile of a single pre-operative dose of ofloxacin.

    Main Methods:

    • A single 300 mg dose of ofloxacin was administered approximately 3 hours before surgery.
    • Tissue samples were collected from 63 patients with diverse urogenital conditions.
    • High-performance liquid chromatography (HPLC) was employed to quantify ofloxacin levels in tissue homogenates.

    Main Results:

    • Mean ofloxacin tissue levels varied across different anatomical sites.
    • Normal renal parenchyma showed the highest concentration (22.10 µg/g).
    • Significant concentrations were also observed in patients with benign prostatic hypertrophy (10.62 µg/g) and other urogenital conditions.

    Conclusions:

    • Ofloxacin is rapidly and extensively distributed into urogenital tissues following oral administration.
    • Achieved tissue concentrations are generally high, supporting its use in treating urogenital infections.
    • The drug's pharmacokinetic behavior suggests potential for effective prophylaxis and treatment in surgical patients.

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