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Ofloxacin therapy of difficult-to-treat infections due to multiresistant organisms
Abstract:
Sixty-four patients with complicated UTI (58) and P. aeruginosa ear infections (6) were treated with oral ofloxacin. All patients were infected with multiply-resistant problem organisms, which had very low minimum inhibitory concentrations (MICs) when tested in vitro with ofloxacin. The immediate cure rate was 86% and the maintained cure rate was 75%, an excellent result considering the complicated nature of the infections. This result has been attributed to the great efficacy of ofloxacin and its excellent pharmacokinetics. There was a very low incidence of mild side effects. Because resistance to quinolones is not mediated by R-factors, it is recommended to select them as first choice in the treatment of patients with complicated UTI with indwelling catheters or nephrostomy tubes, and in patients with discharging ears in order to limit the spread of resistant strains in the hospital environment and in the community.
Insights
Oral ofloxacin effectively treated complicated urinary tract infections (UTI) and Pseudomonas aeruginosa ear infections. This antibiotic demonstrated high cure rates, even with resistant bacteria, offering a promising treatment option.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Complicated urinary tract infections (UTI) and Pseudomonas aeruginosa ear infections often involve multiply-resistant organisms.
- Limited effective oral treatment options exist for these challenging infections, necessitating novel therapeutic strategies.
Purpose of the Study:
- To evaluate the efficacy and safety of oral ofloxacin in patients with complicated UTI and P. aeruginosa ear infections.
- To assess the clinical outcomes and side effect profile of ofloxacin in treating infections caused by multiply-resistant bacteria.
Main Methods:
- A cohort of 64 patients (58 with complicated UTI, 6 with P. aeruginosa ear infections) received oral ofloxacin.
- In vitro minimum inhibitory concentrations (MICs) were determined for ofloxacin against the causative organisms.
- Clinical cure rates (immediate and maintained) and incidence of side effects were recorded.
Main Results:
- Ofloxacin demonstrated very low MICs against the multiply-resistant bacteria isolated from patients.
- An immediate cure rate of 86% and a maintained cure rate of 75% were achieved.
- A low incidence of mild side effects was observed during the treatment period.
Conclusions:
- Oral ofloxacin is highly effective in treating complicated UTI and P. aeruginosa ear infections, even those caused by multiply-resistant strains.
- The excellent efficacy and pharmacokinetics of ofloxacin, coupled with a favorable safety profile, support its use.
- Quinolones, due to their resistance mechanisms, are recommended as a first-choice treatment for complicated UTI and ear infections to curb the spread of resistant strains.