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Effect of sutureless securement on hemodialysis catheter-related bloodstream infection

Keiji Fujimoto1, Emi Iida2,3, Syo Kumano4

  • 1Department of Nephrology, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. k-2210@kanazawa-med.ac.jp.

Scientific Reports
|November 6, 2021
PubMed

Insights

Sutureless securement devices like GRIP-LOK may lower the risk of catheter-related bloodstream infection (CRBSI) in hemodialysis patients. This study found GRIP-LOK significantly reduced CRBSI compared to traditional sutures for non-tunneled hemodialysis catheters.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Medical Devices

Background:

  • Catheter-related bloodstream infection (CRBSI) is a significant complication in hemodialysis patients.
  • Sutureless securement devices may prevent CRBSI by reducing catheter dislodgement and exit-site infections.
  • The efficacy of sutureless devices for hemodialysis catheters remains under-investigated.

Purpose of the Study:

  • To evaluate the effectiveness of the GRIP-LOK sutureless securement device compared to conventional sutures in preventing CRBSI in patients with non-tunneled hemodialysis catheters (NTHCs).

Main Methods:

  • A single-center retrospective observational study analyzed 211 NTHCs in 110 hemodialysis inpatients.
  • Patients were divided into two groups: conventional skin sutures (Suture group, n=121) and GRIP-LOK (GRIP-LOK group, n=90).
  • The stabilized inverse probability of treatment (SIPT)-weighting method was employed to adjust for 12 potential CRBSI predictors, followed by univariate SIPT-weighted Cox proportional regression analysis.

Main Results:

  • The SIPT-weighted analysis revealed a significant reduction in CRBSI risk with GRIP-LOK compared to sutures (Hazard Ratio: 0.17, 95% CI: 0.04-0.78, p=0.023).
  • GRIP-LOK demonstrated a substantial protective effect against CRBSI development.

Conclusions:

  • GRIP-LOK sutureless securement is associated with a lower risk of CRBSI in patients requiring indwelling NTHCs compared to traditional suture securement.
  • Sutureless devices represent a promising alternative for enhancing hemodialysis catheter safety.

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