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Updated: Oct 14, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*

João P M António1, Joana Inês Carvalho1, Ana S André2

  • 1Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.

Angewandte Chemie (International Ed. in English)
|November 6, 2021
PubMed
Summary

Researchers developed a novel reactive-oxygen-species (ROS)-responsive antibody-drug conjugate (ADC) for targeted cancer therapy. This new ADC demonstrates high selectivity and cytotoxicity against B-cell lymphoma cells.

Keywords:
antibody-drug conjugatesboronic acidscleavable linkersdiazaborinesreactive oxygen species

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