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Updated: Oct 14, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

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Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors

Stefan Schiesser1, Peter Hajek1, Huw E Pople2

  • 1Department of Medicinal Chemistry, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183, Mölndal, Sweden.

European Journal of Medicinal Chemistry
|November 6, 2021
PubMed

Keywords:
Allosteric inhibitorDiscovery and optimizationMALT1Mucosa-associated lymphoid tissue lymphoma translocation protein-1ParacaspaseProtease inhibitor

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