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Circulating ANGPTL3 and ANGPTL4 levels predict coronary artery atherosclerosis severity

Ting Sun1, Wanlin Zhan2, Lijiang Wei2

  • 1Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. beibeisun2008@163.com.

Lipids in Health and Disease
|November 7, 2021
PubMed

Insights

Higher levels of angiopoietin-like 3 (ANGPTL3) and lower levels of angiopoietin-like 4 (ANGPTL4) are associated with coronary atherosclerosis. These proteins may serve as future predictors for the condition.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Atherosclerosis Pathogenesis

Background:

  • Investigated the role of ANGPTL3 and ANGPTL4 in atherosclerosis.
  • Examined the relationship between plasma ANGPTL3/ANGPTL4 levels and coronary stenosis severity.

Purpose of the Study:

  • To determine the association between ANGPTL3 and ANGPTL4 levels and the degree of coronary artery stenosis.
  • To evaluate ANGPTL3 and ANGPTL4 as potential predictors of coronary atherosclerosis.

Main Methods:

  • 305 patients with angina undergoing coronary angiography were enrolled.
  • ANGPTL3 and ANGPTL4 levels were quantified using competitive ELISA kits.
  • Patients were categorized based on coronary artery stenosis severity.

Main Results:

  • Higher plasma ANGPTL3 and lower ANGPTL4 levels were observed in patients with coronary artery stenosis ≥10% compared to those with <10%.
  • ANGPTL3 and ANGPTL4 levels significantly correlated with the severity of coronary vascular stenosis.
  • ROC analysis identified specific thresholds for ANGPTL3 and ANGPTL4 as predictors of atherosclerosis, with significant odds ratios indicating independent risk factor status.

Conclusions:

  • Elevated ANGPTL3 and reduced ANGPTL4 levels are linked to coronary atherosclerosis.
  • ANGPTL3 and ANGPTL4 show potential as future biomarkers for predicting coronary atherosclerosis.
Abstract

Keywords:
ANGPTL3ANGPTL4Coronary atherosclerosisPredictors

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