Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.6K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.6K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

6.3K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
6.3K
Skin Cancer01:30

Skin Cancer

4.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.9K
Tumor Progression02:07

Tumor Progression

6.6K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.6K
Bone Cells and Tissue01:30

Bone Cells and Tissue

6.4K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
6.4K
Abnormal Proliferation02:23

Abnormal Proliferation

4.7K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of whole-slide scanner tissue detection algorithms: Implications for scan area, scan time, and file size in high-volume digital pathology workflows.

Journal of pathology informatics·2026
Same author

Deployment of AI-driven automated quality control of whole-slide images in a large tertiary cancer center.

Journal of pathology informatics·2026
Same author

Interobserver Variability Across Whole-Slide Imaging Systems.

Archives of pathology & laboratory medicine·2026
Same author

A subset of high-grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions.

The journal of pathology. Clinical research·2026
Same author

Unintended consequences of legacy oversight in digital medicine.

Nature medicine·2026
Same author

Does Longitudinal Targeted Panel Sequencing Provide Clinically Relevant Information in Translocation-Associated Sarcomas?

JCO precision oncology·2026

Related Experiment Video

Updated: Oct 14, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K

Malignant Cartilage-Forming Tumors.

Meera Hameed1

  • 1Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Surgical Pathology Clinics
|November 7, 2021
PubMed
Summary
This summary is machine-generated.

Chondrosarcomas are diverse cartilage tumors. This review details their pathological features and recent genetic discoveries, aiding in diagnosis and understanding of these malignant neoplasms.

Keywords:
Clear cellConventionalDedifferentiatedHey1-NCOA2 rearrangementIDH1/2 mutationsMesenchymalPeriostealSecondary

More Related Videos

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
06:40

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

9.2K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.3K

Related Experiment Videos

Last Updated: Oct 14, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
06:40

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

9.2K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.3K

Area of Science:

  • Orthopedic Oncology
  • Surgical Pathology
  • Cancer Genetics

Background:

  • Chondrosarcomas are a heterogeneous group of malignant cartilaginous neoplasms.
  • Subtypes vary in prevalence, including conventional, dedifferentiated, clear cell, mesenchymal, and periosteal chondrosarcoma.
  • Histologic grading is crucial for prognosis in conventional chondrosarcoma.

Purpose of the Study:

  • To review the pathological features of malignant cartilage tumors.
  • To provide updates on recent genetic findings in chondrosarcoma.
  • To discuss the clinical behavior and classification of chondrosarcoma subtypes.

Main Methods:

  • Review of existing literature on chondrosarcoma pathology and genetics.
  • Analysis of classification systems and grading criteria.
  • Integration of recent genetic discoveries into the understanding of chondrosarcoma.

Main Results:

  • Conventional chondrosarcoma accounts for the majority of cases (75%).
  • Histologic grade remains the gold standard for predicting outcomes in conventional chondrosarcoma.
  • Grade I chondrosarcomas of tubular bones are now classified as atypical cartilaginous tumors.

Conclusions:

  • Understanding the pathological diversity of chondrosarcomas is essential for accurate diagnosis.
  • Recent genetic findings are enhancing our knowledge of chondrosarcoma biology.
  • Classification and grading are critical for managing these matrix-producing neoplasms.