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Related Experiment Video

Updated: Oct 14, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Interstitial Lung Abnormalities, Emphysema, and Spirometry in Smokers.

Aravind A Menon¹, Rachel K Putman¹, Jason L Sanders¹

¹Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

|November 7, 2021

Summary

This summary is machine-generated.

Interstitial lung abnormalities (ILAs) lessen the expected FVC reduction from emphysema. This finding is crucial for understanding combined lung conditions and their impact on respiratory function.

Keywords:

emphysema interstitial lung abnormalities lung function spirometry

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Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice

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Area of Science:

Pulmonary Medicine
Radiology
Epidemiology

Background:

Pulmonary conditions typically decrease Forced Vital Capacity (FVC).
Combined pulmonary fibrosis and emphysema show less FVC reduction than expected.
Interstitial lung abnormalities (ILAs) may indicate early pulmonary fibrosis.

Purpose of the Study:

To investigate if ILAs affect the association between emphysema and FVC.
To analyze the impact of ILAs on lung function in individuals with emphysema.

Main Methods:

Utilized data from 9,579 (Phase 1) and 5,277 (Phase 2) COPDGene participants.
Defined ILAs using Fleischner Society guidelines.
Employed adjusted linear regression models to assess associations and interactions.

Main Results:

ILAs were present in 6% (Phase 1) and 11% (Phase 2) of participants.
A significant interaction (P < .0001) was found between ILAs and emphysema on FVC.
Emphysema led to FVC reduction without ILAs, but not in their presence.

Conclusions:

The presence of ILAs attenuates the FVC reduction typically associated with emphysema.
ILAs modify the impact of emphysema on lung function, specifically FVC.