The association between bisphenol A exposure and oxidative damage in rats/mice: A systematic review and meta-analysis
Huan Zhang1, Ruifu Yang2, Wanying Shi3
1Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang, 050017, China; Department of Occupational Health and Environmental Health, School of Public Health, Hebei Medical University, Shijiazhuang, 050017, China; Hebei Key Laboratory of Environment and Population Health, Shijiazhuang, 050017, China.
Abstract:
Numerous studies reported that BPA could cause oxidative damage to different tissues in rats/mice. This study aimed to perform a systematic review and meta-analysis of BPA exposure on oxidative damage in rats/mice. A comprehensive literature search was conducted using PubMed, Embase, and Web of Science databases from their inception date until July 18, 2020. 20 eligible articles were included in this study. The results showed that BPA could significantly increase the level of MDA (SMD, 16.88; 95%CI, 12.06-21.71), but there was a significant reduction in the contents of antioxidants, such as GR (-10.46, -13.91 ∼ -7.02), CAT (-8.48, -11.66 ∼ -5.30), GPx (-9.37, -11.95 ∼ -6.80), GST (-7.59, -14.51 ∼ -0.67), GSH (-10.64, -13.96 ~ -7.33), and SOD (-6.48, -8.37 ∼ -4.58) in rats/mice. Our study provided clear evidence that BPA exposure could significantly induce oxidative damage in rats/mice. And we also found that the degree of oxidative damage was related to BPA dose, target tissue, intervention means, and exposure duration of BPA.
