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Altered spontaneous brain activity in patients with asthma: a resting-state functional MRI study using regional
Hui Huang1, Si-Yu Li1, Ling Shi1
1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University.
Objective:
Studies have shown that patients with asthma have changes in brain function activities, but the specific relationship is still unknown. This study aims to investigate the potential regional homogeneity (ReHo) brain activity changes in patients with asthma and healthy controls.
Methods:
Thirty-one patients with asthma and 31 healthy controls closely matched in age, sex, and weight underwent resting-state functional MRI scans, respectively. The ReHo method was applied to evaluate synchronous neural activity changes. Receiver operating characteristic curve was used to show high test-retest stability and a high degree of sensitivity and specificity.
Results:
Compared with the healthy controls, asthma patients had significantly increased ReHo values in left cerebellum posterior lobe and left superior frontal gyrus, and decreased ReHo values of right middle temporal gyrus, right Putamen, right inferior temporal gyrus, right inferior middle frontal gyrus, left middle occipital gyrus, and right precentral/middle frontal gyrus.
Conclusion:
Patients with asthma have different functional changes in different brain regions, mainly including the cerebellum, frontal lobe, temporal lobe, and occipital lobe, which provides important pieces of evidence to support the role of brain networks in the pathophysiology of asthma and offers an entirely new target for potential therapeutic intervention in asthma.
