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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Dissolving microneedle rollers for rapid transdermal drug delivery.

Xiao Peng Zhang1, Bao Li Zhang1, Bo Zhi Chen1

  • 1Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.

Drug Delivery and Translational Research
|November 7, 2021
PubMed
Summary

A novel polyvinyl alcohol (PVA)-based dissolving microneedle roller (DMNR) offers a painless method for rapid drug delivery on large or curved skin areas. Insulin-loaded DMNRs effectively lowered blood glucose in diabetic rats within one hour.

Keywords:
Diabetic ratDissolving microneedle rollerInsulinTransdermal drug delivery

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Dissolving microneedle patches (DMNPs) are minimally invasive drug delivery devices.
  • DMNPs face challenges in application to large or curved skin surfaces due to deformation.
  • Existing DMNPs require prolonged skin attachment during drug delivery.

Purpose of the Study:

  • To develop a novel polyvinyl alcohol (PVA)-based dissolving microneedle roller (DMNR) for efficient transdermal drug delivery.
  • To evaluate the DMNR's applicability for large surface areas and curved skin.
  • To assess the hypoglycemic effect of insulin-loaded DMNRs in a type 1 diabetic rat model.

Main Methods:

  • Fabrication of PVA-based dissolving microneedle rollers (DMNRs).
  • Loading of insulin into the DMNRs for transdermal delivery.
  • Administration of insulin-loaded DMNRs to type 1 diabetic rat models.
  • Monitoring of blood glucose levels over time post-administration.

Main Results:

  • The DMNR device allows for rapid drug delivery on large or curved skin areas.
  • Insulin-loaded DMNRs demonstrated an immediate and effective hypoglycemic effect.
  • Blood glucose levels in diabetic rats reduced by over 50% within 1 hour after DMNR administration.

Conclusions:

  • The DMNR is a promising alternative to traditional DMNPs for transdermal drug delivery.
  • DMNRs overcome limitations of DMNPs regarding skin surface applicability and attachment time.
  • This technology shows potential for efficient management of diabetes through transdermal insulin delivery.