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Updated: Oct 14, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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[Neurogenic overactive bladder: focus on cognitive function].

E S Korshunova1,2,3, M N Korshunov1,2,3, E P Nuzhnyi1,2,3

  • 1FGBNU Research Center of Neurology, Moscow, Russia.

Urologiia (Moscow, Russia : 1999)
|November 7, 2021
PubMed
Summary
This summary is machine-generated.

Trospium chloride effectively treats neurogenic overactive bladder without impacting cognitive functions in Parkinson's disease or multiple sclerosis patients. This medication is safe for neurological conditions with cognitive impairment risks.

Keywords:
M-anticholinergicsParkinsons diseasecognitive impairmentmultiple sclerosisneurogenic overactive bladdertrospium chloride

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Area of Science:

  • Neurology
  • Urology
  • Pharmacology

Background:

  • Overactive bladder and cognitive impairment significantly impact quality of life and are common in neurological disorders like Parkinson's disease and multiple sclerosis.
  • Understanding drug properties is crucial for managing these complex patient populations.

Purpose of the Study:

  • To assess the effect of trospium chloride on cognitive functions in patients with neurogenic overactive bladder.
  • To evaluate the safety and efficacy of trospium chloride in patients with Parkinson's disease and multiple sclerosis.

Main Methods:

  • A 12-week study involving 45 patients with neurological diseases (Parkinson's disease or multiple sclerosis) and overactive bladder symptoms.
  • Cognitive functions were evaluated using the Montreal Cognitive Assessment (MoCA) before and after treatment with trospium chloride.
  • Statistical analysis included the paired Wilcoxon test to determine significant changes in MoCA scores.

Main Results:

  • Trospium chloride significantly improved overactive bladder symptoms in both patient groups.
  • No significant changes in cognitive functions were observed after 12 weeks of trospium chloride therapy in either Parkinson's disease or multiple sclerosis patients.
  • No central nervous system side effects were reported during the study.

Conclusions:

  • Trospium chloride is an effective treatment for neurogenic overactive bladder.
  • Trospium chloride does not adversely affect cognitive functions in patients with Parkinson's disease or multiple sclerosis.
  • The drug is considered safe for use in these neurological conditions, even with polypharmacy concerns.