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Early functional and metabolic disorders in children with type I diabetes mellitus and diabetic nephropathy

Ievgeniia Burlaka1, Vitaliy Maidannyk1

  • 1Department of Pediatrics No. 4, Bogomolets National Medical University, Ukraine.

Pediatric Endocrinology, Diabetes, and Metabolism
|November 8, 2021
PubMed

Insights

Diabetic nephropathy (DN) in children with type 1 diabetes (T1D) shows initial metabolic and functional disorders. Early detection of these changes is crucial for managing kidney function in pediatric diabetes patients.

Area of Science:

  • Pediatric Endocrinology
  • Nephrology
  • Metabolic Disorders

Background:

  • Type 1 diabetes (T1D) is a chronic condition primarily affecting children and young adults, characterized by hyperglycemia.
  • Diabetic nephropathy (DN) is a significant microvascular complication of diabetes, often leading to end-stage renal disease (ESRD).
  • Understanding early metabolic and functional changes in pediatric T1D with DN is critical for timely intervention.

Purpose of the Study:

  • To evaluate the earliest metabolic and functional disorders in children diagnosed with T1D and DN.
  • To identify specific patterns of blood pressure changes, kidney function impairment, and metabolic disturbances in this cohort.

Main Methods:

  • The study included 76 children (aged 3-17 years) with T1D and DN.
  • Endothelin-1 (ET-1) levels were measured via ELISA; lipid oxidation ratio was assessed spectrophotometrically.
  • Clinical parameters including blood pressure, glycaemia, albuminuria, creatininaemia, HbA1C, cholesterol, and calculated glomerular filtration rate (GFR) were analyzed.

Main Results:

  • The study identified distinct patterns of blood pressure changes in children with T1D and DN.
  • Specific alterations in kidney function, ET-1 levels, and metabolic parameters were observed.
  • Functional and metabolic disorders were characterized in the studied pediatric population.

Conclusions:

  • The findings highlight specific early-onset metabolic and functional disruptions in children with T1D and DN.
  • These insights are vital for developing targeted management strategies to prevent progressive kidney damage.
  • Further research can build upon these patterns to improve long-term outcomes for pediatric patients with diabetic nephropathy.

Keywords:
ET-1GFRdiabetic nephropathylipids oxidation.metabolic disordersstage progressiondiabetes mellitus

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