Relationship between CANLPH score and in-hospital mortality in patients undergoing coronary artery bypass grafting

Area of Science:

• Cardiology
• Biomarkers
• Surgical Outcomes

Background:

• In-hospital mortality after coronary artery bypass grafting (CABG) remains a critical concern.
• Accurate risk stratification is essential for optimizing patient management and outcomes.
• Existing risk scores may require refinement for specific patient populations.

Purpose of the Study:

• To evaluate the efficacy of the novel Composite Assessment of Nutritional and Inflammatory Factors (CANLPH) score in predicting in-hospital mortality post-CABG.
• To compare the predictive performance of the CANLPH score against the established European System for Cardiac Operative Risk Evaluation II (EuroSCORE II).

Main Methods:

• A retrospective cohort study included 999 patients undergoing CABG.
• The CANLPH score was calculated based on neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio, and platelet/hemoglobin ratio.
• Receiver-operating characteristic (ROC) curve analysis was employed to assess predictive accuracy.

Main Results:

• The CANLPH score demonstrated non-inferiority to EuroSCORE II in predicting in-hospital mortality (AUC difference: 0.0162, p=0.494).
• Twenty-five patients (2.5%) experienced the primary endpoint of in-hospital mortality.

Conclusions:

• The CANLPH score is a potentially valuable tool for assessing in-hospital mortality risk after CABG.
• This novel score may offer a more appropriate risk assessment compared to current methods.