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The Association Between Hyperhidrosis and Dementia: A Community-Based Research.

Jinghuan Gan¹, Shuai Liu², Xiao-Dan Wang²

¹Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.

Journal of Alzheimer'S Disease : JAD

|November 8, 2021

Summary

Hyperhidrosis (HH) is common in elderly Chinese adults and is linked to an increased risk of dementia, especially dementia with Lewy bodies (DLB). Increased awareness of HH is crucial for dermatologists and neurologists.

Keywords:

Autonomic nervous system dysfunction cognitive impairment dementia dementia with Lewy bodies hyperhidrosis

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Area of Science:

Gerontology
Neurology
Dermatology

Background:

Dementia and hyperhidrosis (HH) are prevalent in the elderly population.
Limited research exists on the association between hyperhidrosis and dementia.
This study investigates the link between HH and dementia in older adults in China.

Purpose of the Study:

To clarify a possible association between hyperhidrosis and dementia in adults aged 65 and older in China.

Main Methods:

A cross-sectional survey of 5,958 elderly adults (≥65 years) in China was conducted.
Logistic and linear regression analyses were employed to assess the association between HH and dementia.
Goodness-of-fit tests were used to ensure model adequacy.

Main Results:

The prevalence of all-cause dementia was 10.17%, dementia with Lewy bodies (DLB) was 1.41%, and HH was 14.97%.
Participants with HH showed higher prevalence rates of dementia and DLB.
HH was associated with a 1.275 times higher likelihood of dementia and a 3.616 times higher likelihood of DLB.

Conclusions:

Hyperhidrosis is common in the Chinese elderly population (≥65 years).
Hyperhidrosis increases the risk of dementia, particularly DLB, in the elderly.
Enhanced awareness of HH among dermatologists and neurologists is recommended.