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Updated: Oct 14, 2025
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Quantitative CT in mortality prediction in pulmonary fibrosis with or without emphysema
Fatma Üçsular1, Gülistan Karadeniz1, Gülru Polat1
1University of Health Sciences, Dr Suat Seren Chest Disease and Surgery Training and Research Hospital, Pulmonary Disease, Izmir, Turkey.
Aim:
We aimed to evaluate the quantitative CT analysis of patients with CPFE in comparison with IPF and emphysema.
Methods:
Patients with CPFE(n:36), IPF(n:38) and emphysema(n:32) were retrospectively included in the study with the approval of the ethics committee.
Results:
There was a positive correlation between total lung volume and FVC%, TLCO% and 6 MWT, and negative correlation between mMRC and mortality. Negative correlation was found between right, left lung density and FVC%, TLCO% and 6 MWT, and positive correlation between mortality. Also, total lung volume, right and left lung densities were significant in predicting mortality and cut-off values are ≤3831,> -778 and> -775, respectively (p = 0.040, 0.020, 0.013).
Conclusion:
Quantitative CT are guiding in predicting mortality of the disease.
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