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Related Concept Videos

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
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Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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Toxic Epidermal Necrolysis Syndrome: Management And Outcomes.

S Al-Benna1

  • 1Division of Plastic Surgery, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

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|November 8, 2021
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Summary

This study evaluated outcomes for toxic epidermal necrolysis syndrome (TENS) without using IV immunoglobulin or steroids. Results showed a 25% mortality rate, highlighting the need for effective TENS treatments.

Keywords:
epidermal necrolysisoutcome assessment (health care)toxic

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Area of Science:

  • Dermatology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Toxic epidermal necrolysis syndrome (TENS) is a severe, life-threatening mucocutaneous reaction.
  • High morbidity and mortality rates are associated with TENS.
  • Current treatment protocols for TENS lack universal consensus.

Purpose of the Study:

  • To assess patient outcomes in TENS treated without intravenous immunoglobulin (IVIG) or systemic corticosteroids.
  • To evaluate the effectiveness of a specific treatment protocol for TENS.
  • To analyze mortality and morbidity in a cohort of TENS patients.

Main Methods:

  • Retrospective analysis of TENS patients admitted to a tertiary burns center between 2015 and 2017.
  • Inclusion criteria: diagnosis of TENS.
  • Data collected included patient demographics, affected body surface area, SCORTEN index, and treatment protocols.

Main Results:

  • Twelve TENS cases were identified with a mean age of 46±8 years.
  • Average total body surface area affected was 51±9%.
  • The SCORTEN index predicted 3 deaths, and the observed mortality rate was 25%.

Conclusions:

  • The SCORTEN index demonstrated prognostic validity in this TENS cohort.
  • No specific TENS treatment, including the protocol used, has been unequivocally proven effective.
  • Further research is needed to establish optimal TENS management strategies.