Related Experiment Video
Updated: Oct 14, 2025
07:48
Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
Published on: October 28, 2022
1.3K
Rifle Criteria For Acute Kidney Injury In Burn Patients: Prevalence And Risk Factors
O N Putra1, I D Saputro2, D Diana1
1Department of Clinical Pharmacy, Study Program of Pharmacy, Hang Tuah University, Surabaya, Indonesia.
Annals of Burns and Fire Disasters
|November 8, 2021
Summary
Acute kidney injury (AKI) affects 20% of burn patients, with older age being a key risk factor. Inhalation injury, TBSA, and age significantly increase mortality risk in these patients.
Area of Science:
- Nephrology
- Trauma Surgery
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a serious complication following severe burns.
- Early identification of risk factors and outcomes in burn patients with AKI is crucial for improving patient management.
Purpose of the Study:
- To determine the prevalence of AKI in burn patients.
- To identify risk factors associated with AKI development and mortality in burn patients.
- To utilize the RIFLE classification for AKI staging.
Main Methods:
- A 3-year retrospective study of burn patients (>18 years) diagnosed with AKI at Dr. Soetomo Hospital Burn Center (January 2018 - September 2020).
- Analysis of factors influencing AKI and mortality using bivariate and multivariate logistic regression.
- RIFLE (Risk, Injury, Failure, Loss, End-stage kidney disease) classification was used for AKI staging.
Main Results:
- 18 out of 89 (20%) burn patients developed AKI.
- Patients with AKI were significantly older and had a higher % of Total Body Surface Area (TBSA) burned.
- Age over 60 was a significant risk factor for AKI (OR=25.553).
- Mortality rate in AKI patients was 83%, with inhalation injury, TBSA, and age identified as mortality risk factors.
Conclusions:
- The incidence of AKI in burn patients is notably high.
- Older age is a significant risk factor for developing AKI post-burn.
- Inhalation injury, TBSA, and patient age are critical factors associated with mortality in burn patients with AKI.
Related Concept Videos
01:22Acute Kidney Injury I: Introduction
136
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
136
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
82
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
82
01:29Acute Kidney Injury II: Pathophysiology
202
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
202
01:22Burn Injuries
3.1K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
3.1K
01:29Acute Kidney Injury III: Clinical Manifestations
190
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
190
01:20Acute Kidney Injury V: Interprofessional Care
68
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
68