Related Experiment Video
Updated: Oct 14, 2025
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with
Hong Sun1, Weiqun Wang1, Chenglei Lin1
1Department of Pediatrics, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang 310003, China.
Insights
Children with infectious mononucleosis (IM) and an allergic constitution show elevated immune factors. Serum IgE levels correlate with lymphocyte subsets and immunoglobulins, indicating a link between allergy and IM severity.
Area of Science:
- Pediatric Immunology
- Infectious Diseases
- Allergy and Immunology
Background:
- Infectious mononucleosis (IM) is a common viral illness in children.
- Allergic constitutions are prevalent and can influence disease course.
- Understanding the interplay between IM and allergy is crucial for effective management.
Purpose of the Study:
- To investigate the correlation between serum immune factor levels and allergic constitution in children diagnosed with infectious mononucleosis.
- To explore potential biomarkers for assessing IM severity in allergic children.
Main Methods:
- A case-control study involving 120 children with IM and 40 healthy controls.
- Participants were categorized into an IM group (IG) and an IM allergy group (AG) based on allergic disease history.
- Serum levels of IgE, lymphocyte subsets (CD3, CD4, CD8), and immunoglobulins (IgA, IgM, IgG) were measured.
Main Results:
- Children in the IM allergy group (AG) exhibited significantly higher serum CD3, CD4, CD8, IgE, IgA, IgM, and IgG levels compared to the IM group (IG) and control group (CG).
- Positive correlations were observed between serum IgE levels and CD3, CD4, CD8 counts in the AG.
- Serum IgE levels also showed a positive correlation with IgA, IgM, and IgG levels in children with AG.
Conclusions:
- An allergic constitution may be associated with the incidence, clinical presentation, and prognosis of infectious mononucleosis.
- Serum IgE levels can serve as a valuable reference index for evaluating the early clinical severity of IM symptoms in children.
Objective:
To investigate the correlation between serum immune factor levels and allergic constitution in children with infectious mononucleosis.
Methods:
A total of 120 children who visited our hospital from March, 2019, to December, 2020, were selected as the research objects, and 40 children who came to our hospital for physical examination were included in the control group (CG). 40 children with IM were classified into the IM group (IG), and 40 IM children with allergic rhinitis, allergic dermatitis, asthma, and other allergic diseases were classified into the IM allergy group (AG). On the second day of admission, 5 ml of fasting venous blood was collected from all children in the early morning to observe the serum IgE level, the level of lymphocyte subsets, and the level of immunoglobulin of the patient.
Results:
The serum CD3, CD4, and CD8 levels of children in AG were significantly higher than those in IG and CG (P < 0.05). The serum IgE, IgA, IgM, and IgG levels of children in AG were significantly higher than those of IG and CG (P < 0.05). The serum IgE levels of children in AG were positively correlated with the serum CD3, CD4, and CD8 levels (P < 0.05). There was a positive correlation between the serum IgE level and serum IgA, IgM, and IgG levels in children with AG (P < 0.05).
Conclusion:
The results of this study showed that there may be a certain relationship between allergic constitution and the incidence, clinical manifestations, and prognosis of infectious mononucleosis. IgE level can be used as a reference index for the early severity of IM clinical symptoms.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
