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MANF: A Novel Endoplasmic Reticulum Stress Response Protein-The Role in Neurological and Metabolic Disorders

Yang Yu1,2,3, Dan-Yang Liu1,3, Xue-Shen Chen3,4

  • 1NHC Key Laboratory of Chronobiology (Sichuan University), West China School of Basic Medical Sciences & Forensic Medicine, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Oxidative Medicine and Cellular Longevity
|November 8, 2021
PubMed

Insights

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a conserved protein linked to ER stress. This review explores MANF

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionary conserved protein.
  • MANF is associated with the unfolded protein response and endoplasmic reticulum (ER) stress.
  • Emerging evidence highlights MANF's protective role in ER stress-related diseases.

Purpose of the Study:

  • To review the structure-function relationship of MANF.
  • To explore MANF's role in neurological and metabolic disorders.
  • To summarize MANF's therapeutic and diagnostic potential.

Main Methods:

  • Literature review of existing studies on MANF.
  • Analysis of MANF's structural features.
  • Synthesis of data on MANF's involvement in disease pathogenesis.

Main Results:

  • MANF exhibits protective effects in various ER stress-related conditions.
  • MANF's structure is intrinsically linked to its function in cellular protection.
  • MANF has demonstrated potential in preclinical models of neurological and metabolic diseases.

Conclusions:

  • MANF is a promising therapeutic target for ER stress-mediated disorders.
  • Understanding MANF's structure-function dynamics is crucial for developing novel treatments.
  • MANF holds significant potential for future disease diagnosis and therapy development.

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