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Manufacturers' views on outcome-based agreements
Sahar Barjestehvan Waalwijk van Doorn-Khosrovani1, Lonneke Timmers2, Anke Pisters-van Roy1
1Department of Medical Advisory and Innovation, CZ Health Insurance, Tilburg, The Netherlands.
Pharmaceutical manufacturers are open to outcome-based agreements (OBAs) for off-label drug use but hesitant for registered indications due to financial risks and administrative challenges. Addressing these concerns is key for OBA feasibility.
Area of Science:
- Health Economics
- Pharmaceutical Policy
- Oncology Market Access
Background:
- Outcome-based agreements (OBAs) are used to manage high drug costs in healthcare.
- Manufacturer willingness to engage in OBAs remains unclear.
Purpose of the Study:
- To explore the feasibility of OBAs from pharmaceutical manufacturers' perspectives.
- To understand manufacturer attitudes towards OBAs in oncology.
Main Methods:
- Interviews with Dutch market-access experts from eight major pharmaceutical companies in oncology.
- Qualitative data compilation and expert review of the manuscript.
Main Results:
- Manufacturers see OBAs as valuable for off-label use, especially when no alternatives exist.
- Collaboration is more likely for licensed indications with market-access incentives, but less so with high financial risks.
- Concerns include defining outcomes, compliance impact, administrative burden, revenue recognition, and combination therapy reimbursement.
Conclusions:
- Market-access experts are generally positive about OBAs but reluctant for registered indications with low response rates.
- Key challenges include defining clinical outcomes, feasibility, and administrative burden.
- International collaboration and shared databases are recommended to standardize OBAs and evidence accumulation.
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