Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flight in the dark: different responses to darkness in flying insects.

The Journal of experimental biology·2026
Same author

Patients with lower limb discrepancies-Long-term follow-up, quality of life, and function while mobilizing with Extension-prosthesis.

Prosthetics and orthotics international·2026
Same author

How tp1, an indirect wing steering muscle, stabilizes <i>Drosophila's</i> flight.

bioRxiv : the preprint server for biology·2025
Same author

Unique Challenges of Hebrew Translation and Cross-Cultural Adaptation of LIMB-Q Kids for Children with Lower Limb Differences.

Children (Basel, Switzerland)·2025
Same author

Impact of skull base cisterns invasion and extent of resection on the management of skull base intracranial epidermoid tumors.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
Same author

Endovascular treatment of posterior circulation aneurysms with flow diverters with hydrophilic polymer coating in patients receiving prasugrel single antiplatelet therapy: a multicenter case series presenting complication and occlusion rates.

Journal of neurointerventional surgery·2025

Related Experiment Video

Updated: Oct 14, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
07:26

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

8.3K

Measuring pupil size and light response through closed eyelids.

Yousef Farraj1,2, Amnon Buxboim3,4,5,2, Jose E Cohen6

  • 1Casali Center for Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.

Biomedical Optics Express
|November 8, 2021
PubMed
Summary

Continuous monitoring of pupillary size and reactivity through closed eyelids offers an automated method for early detection of brain damage in comatose patients. This novel technology aids in timely intervention and resource management.

More Related Videos

Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice
09:28

Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice

Published on: June 23, 2023

3.2K
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.6K

Related Experiment Videos

Last Updated: Oct 14, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
07:26

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

8.3K
Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice
09:28

Author Spotlight: An Accurate and Quantitative Approach to Study Visual Feature Selectivity of the Optokinetic Reflex in Mice

Published on: June 23, 2023

3.2K
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.6K

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Neurologic assessment of comatose patients relies on pupillary evaluation.
  • Manual pupillary assessment is infrequent, delaying detection of critical changes.
  • Irreversible brain damage can occur if timely alerts are not provided.

Purpose of the Study:

  • To introduce a novel method for continuous pupillary monitoring through closed eyelids.
  • To enable automated assessment of pupillary size and light-reactivity.
  • To improve early detection of potential brain damage in comatose patients.

Main Methods:

  • Utilized near-infrared (near-IR) side illumination through the temple.
  • Employed imaging techniques through the closed eyelid.
  • Developed an automated device for continuous monitoring.

Main Results:

  • Successfully tested the novel method in a clinical trial.
  • Demonstrated feasibility of monitoring pupillary size and reactivity through closed eyelids.
  • Validated the potential for automated, continuous pupillary assessment.

Conclusions:

  • The developed technology can be implemented as an automated device.
  • Continuous pupillary monitoring may save staff resources.
  • Provides earlier alerts for potential brain damage in comatose patients, facilitating timely intervention.