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An Atypical Presentation of Rheumatoid Arthritis as an Asymmetrical Arthropathy
Marc Wong1, Chong Jia Loon1, C Rajasoorya1
1Internal Medicine, Sengkang General Hospital, Singapore, SGP.
Cureus
|November 8, 2021
Summary
This study details a rare case of asymmetrical rheumatoid arthritis (RA) in a 71-year-old woman. Neurologically impaired joints showed milder RA symptoms, suggesting a link between nerve damage and rheumatoid joint disease.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease typically affecting joints symmetrically.
- Neurological conditions can influence systemic inflammatory processes.
- Cervical radiculopathy, a nerve disorder, can result from trauma.
Observation:
- A 71-year-old Chinese female presented with distinctly asymmetrical rheumatoid arthritis.
- The joints on the side of her childhood-induced cervical radiculopathy paresis were notably spared from severe RA manifestations.
- Clinical and radiological assessments revealed this asymmetry.
Findings:
- The affected side with neurological impairment exhibited significantly less severe rheumatoid arthritis.
- This case challenges the typical symmetrical presentation of rheumatoid arthritis.
- A potential correlation between neurological deficit and rheumatoid joint involvement is observed.
Implications:
- This case suggests a potential neuro-immune interaction in the pathogenesis of rheumatoid arthritis.
- Understanding this link may lead to novel therapeutic strategies for RA.
- Further research into the mechanisms of neurological sparing in autoimmune joint disease is warranted.
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