Natural Products: A Promising Therapeutics for Targeting Tumor Angiogenesis

Area of Science:

• Oncology
• Pharmacology
• Natural Products Chemistry

Background:

• Tumor-associated angiogenesis, driven by an imbalance of pro- and anti-angiogenic signals, is crucial for tumor growth, metastasis, and cancer stem cell proliferation.
• Natural products are recognized for their potential in cancer therapy due to their low toxicity and cost-effectiveness.
• Understanding established in vitro and in vivo angiogenesis models is essential for evaluating anti-cancer agents.

Purpose of the Study:

• To review and classify natural products with anti-angiogenic properties.
• To explore the mechanisms by which these natural agents target tumor angiogenesis-associated cytokines and apoptotic pathways.
• To provide insights into natural product research for developing novel anti-tumor angiogenesis drugs.

Main Methods:

• Literature review and classification of natural anti-angiogenic agents based on chemical structures (Polyphenols, Polysaccharides, Alkaloids, Terpenoids, Saponins).
• Analysis of mechanistic principles of natural products in regulating angiogenesis-associated cytokines and apoptotic signaling pathways.
• Summary of established in vitro and in vivo models for studying tumor angiogenesis.

Main Results:

• Identification and categorization of various classes of natural products exhibiting anti-angiogenic effects.
• Elucidation of the molecular mechanisms underlying the anti-angiogenic activity of these natural compounds.
• Discussion of the relevance of different angiogenesis models in the context of natural product research.

Conclusions:

• Natural products represent a valuable resource for developing targeted anti-cancer therapies by inhibiting tumor angiogenesis.
• Further research into the mechanisms of action and chemical structures of these agents can accelerate drug discovery.
• This review consolidates current knowledge, facilitating future development of natural product-based anti-angiogenic drugs.