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Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Yingning Li1, Zhen Wang1, Naqi Lian1

  • 1Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anesthesiology, Tianjin, China.

Frontiers in Medicine
|November 8, 2021
PubMed

Insights

Hydrogen gas shows promise for treating COVID-19 by reducing harmful inflammation. This therapy, explored in China, offers a potential new approach for managing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Area of Science:

  • Biomedical Science
  • Respiratory Medicine
  • Inflammation Research

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, lacks specific effective treatments.
  • The disease involves an excessive inflammatory response, often termed an 'inflammatory storm', crucial to its progression.
  • Hydrogen has demonstrated therapeutic potential across various diseases by modulating inflammatory processes.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms of COVID-19.
  • To review the therapeutic effects and mechanisms of hydrogen in treating critical COVID-19.
  • To analyze the feasibility and potential targets for hydrogen therapy in COVID-19 management.

Main Methods:

  • Review of existing literature on COVID-19 pathophysiology.
  • Analysis of studies investigating hydrogen's anti-inflammatory properties.
  • Examination of clinical research and treatment plans involving hydrogen-oxygen gas inhalation for COVID-19.

Main Results:

  • Hydrogen therapy, including inhalation of hydrogen-oxygen gas mixtures, is being explored as a treatment for COVID-19.
  • Emerging evidence suggests hydrogen can inhibit excessive inflammatory cells and factors implicated in severe COVID-19.
  • Hydrogen therapy has been incorporated into new COVID-19 treatment plans in China.

Conclusions:

  • Hydrogen exhibits potential as an effective therapeutic agent for COVID-19 due to its anti-inflammatory actions.
  • Further research into the mechanisms and therapeutic targets of hydrogen is warranted for optimizing COVID-19 treatment.
  • Hydrogen therapy represents a promising complementary or alternative strategy for managing COVID-19, particularly its severe inflammatory manifestations.

Keywords:
COVID-19cytokinesinflammationmolecular hydrogentreatment

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