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Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure

Gulinigaer Tuerhongjiang1,2, Manyun Guo1,2, Xiangrui Qiao1,2

  • 1Department of Cardiovascular, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Frontiers in Cardiovascular Medicine
|November 8, 2021
PubMed

Insights

Heart failure is linked to gut bacteria changes and altered amino acids. This gut-amino acid-heart failure axis may impact disease progression and offer new biomarkers.

Area of Science:

  • Cardiology
  • Microbiology
  • Metabolomics

Background:

  • Heart failure (HF) incidence is increasing globally.
  • Cardiometabolic disorders exacerbate cardiac dysfunction and HF progression.
  • Emerging research highlights the role of gut microbiota (GM) and its metabolites in cardiovascular disease.

Purpose of the Study:

  • To explore the interrelationship between amino acid (AA) metabolism and GM alterations in HF development.
  • To investigate the gut-amino acid-HF axis in HF progression.
  • To discuss the prognostic and therapeutic potential of this axis.

Main Methods:

  • Review of existing literature on gut microbiota, amino acid metabolism, and heart failure.
  • Analysis of the impact of HF-induced hypoperfusion on intestinal permeability and bacterial translocation.
  • Examination of altered microbiota composition and amino acid profiles in HF patients.

Main Results:

  • HF is associated with changes in gut microbiota composition and amino acid profiles.
  • Increased intestinal permeability in HF allows bacterial metabolites into circulation.
  • The gut-amino acid-HF axis is implicated in HF progression.

Conclusions:

  • The gut-amino acid-HF axis plays a significant role in the development and progression of heart failure.
  • Amino acids show potential as diagnostic and prognostic biomarkers for HF.
  • Targeting the gut-amino acid-HF axis may offer novel therapeutic strategies for heart failure.

Keywords:
amino acidscardiometabolic disordersgut microbiotaheart failuremetabolism

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