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Updated: Oct 14, 2025

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Published on: June 21, 2017
Photodecarboxylative Amination of Redox-Active Esters with Diazirines
Vishala Maharaj1, Preeti P Chandrachud2, Wen Che2
1Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Abstract:
Diazirines have been recently demonstrated to serve as electrophilic amination reagents that afford diaziridines, versatile heterocycles that are readily transformed into amines, hydrazines, and nitrogen-containing heterocycles. Here, we report the photodecarboxylative amination of redox-active esters with diazirines using inexpensive photoactivators under mild conditions with an enhanced scope for primary substrates. The stability of diazirines to blue light is demonstrated, paving the way for further research into other photochemical amination methods with these unique heterocycles.
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